Alex Panteliodis pitched his first complete game and Florida took advantage of two errors to beat Miami 7-2 in the opener of their best-of-three series.
Austin Maddox and Mike Zunino drove in two runs each for the Gators (46-15), who improved to 32-3 at home and moved one victory away from their sixth trip to the College World Series.
The in-state rivals play again Saturday in the NCAA Super Regional. Florida can only hope for another performance like it had Friday night.
The Gators jumped on Miami early, played flawless defense and got a career night from Panteliodis. The sophomore left-hander retired the final 14 batters and struck out a career-high 12. He allowed three hits, including a two-run home run to Yasmani Grandal.
n Florida St 9, Vanderbilt 8: Mike McGee's walkoff home run in the ninth inning lifted Florida State to victory over Vanderbilt Friday in the first game of their best-of-three NCAA Super Regional.
The Seminoles (46-17) can advance to the College World Series for the second time in three years with a win Saturday. Vanderbilt needs two straight wins to earn its first CWS trip.
The Commodores (45-19) lost despite 16 hits and four home runs that brought them back from a 6-0 deficit after two innings.
McGee's 15th homer of the season was a towering shot over the fence in right-center.
Daniel Bennett (5-1) got the win and Chase Reid (4-2) took the loss.